Simulation of platelet deposition and activation using an extended Sorensen model
Pages 63-69
Alice Ivan Fernolendt, Adrian Neculae
Abstract
Platelet deposition and aggregation are two phenomena that take place during blood coagulation process which has both positive and negative impacts inside the human body. These phenomena, involved for example in the formation of mural thrombi, are investigated in the present paper using an improved form of the Sorensen model [1]. First, we consider a simplified transport model neglecting the thromboxane contribution, which has the smallest concentration values of all platelet agonists. Its capacity to generate solutions close to the ones obtained with the full Sorensen model is analyzed. Then, the model is extended with two supplementary equations describing the formation-convection-deposition of fibrine – a funda-mental element in the coagulation. A set of calculated fibrine concentration profiles is depicted and the limitations of the model are presented along with the directions to improve this model.